Estrogen and progesterone are synthesized from cholesterol, which first converts into pregnenolone—a step requiring healthy mitochondria and the action of specific CYP (cytochrome P450) heme proteins, such as CYP11A1, CYP17A1, and CYP19A1. While the broader CYP enzyme family is primarily known for detoxification roles in the liver, these particular enzymes reside in steroidogenic tissues like the ovaries, adrenal glands, placenta, and even the brain, where they drive the hormonal pathways essential for female physiology. Their function depends on a redox-balanced mitochondrial environment and critical cofactors—bioavailable iron, vitamin A (retinol), and active thyroid hormone (T3).

The earth is our home, but how often do we meet with it in our day? A child is naturally drawn to the outdoors and can spend hours playing on and with the different earth materials. Their hands and feet and whole bodies experience the joy of contact with these many substances. 

Cancer cells exhibit a fundamentally altered metabolic landscape, largely driven by their need to sustain rapid proliferation and evade apoptosis. A key player in this transformation is deuterium (²H), the heavy isotope of hydrogen, which when a cell is under bioenergetic stress can enter the mitochondria and disrupt function, energy generation, alter intracellular pH regulation, and interfere with proton tunneling, leading to the infamous "Warburg effect" of cancer metabolism. The bioenergetics of the cell can be disrupted by many environmental and epigenetic influences such as indoor living, disconnecting from the earth’s surface for extended periods of time, mal-illumination or lack of full spectrum light exposure, over exposure to toxins, chemicals or artificial visible and non-visible lighting, processed food consumption or even poor sleep quality. All of these drop voltage on the cell membrane which normally prevents deuterium from entering the cytosol and being fed into the proton gradient within our energy and water generating power plants in our cells called mitochondria.

Cancer is often misunderstood as a genetic disease, but at its core, it is a disorder of cellular energy and signaling. Despite the $7.3 billion spent annually on cancer research in the United States, the prevailing medical model remains locked in outdated paradigms, emphasizing genetic mutations while overlooking the fundamental biophysical processes that drive oncogenesis. This reductionist approach has led to standardized treatments that yield limited success, while alternative models exploring the metabolic and biophysical roots of cancer have gained traction.

Amyotrophic Lateral Sclerosis (ALS) remains a devastating neurodegenerative condition without a known cure. Conventional frameworks struggle to resolve its complexity due to their reliance on centralized, algorithmic approaches that fail to capture individualized environmental and mitochondrial dynamics. This document reframes ALS through a decentralized, biophysical lens, integrating mitochondrial redox signaling, light-mediated damage, myelin integrity, and evolutionary biology to uncover a coherent, testable mechanism for disease onset and progression.

The biophysics perspective of health explains how modern alterations to our physics environment, especially as it pertains to light and magnetic flux, have led to most, if not all chronic diseases.. This approach is governed by the principles of Light, Water, and Magnetism, collectively referred to as Circadian Biology or Epigenetics, which emphasizes that environmental stimuli control genetic expression. The principle is that health issues often stem from environmental factors rather than internal ones, and recovery necessitates changing the environment in which the sickness developed.