A New Perspective on Kidney Disease

In today's modern world, with approximately 90% of our time spent indoors and constant exposure to artificial non-native electromagnetic fields (nnEMF) such as wireless radiation, satellite/radar signals, the AC power grid's electric and magnetic fields, artificial light sources, and technology screens, it is biologically certain that mitochondrial dysfunction, reduced voltage in blood plasma, oxidative stress, chronic inflammation, and hypoxia are occurring at a cellular level in everyone.

Arthur Firstenberg, in his book "The Invisible Rainbow," demonstrated that in 1989, when the alternating current electrical power transmission grid was turned on, it took only 15 years for very unusual diseases never seen before to appear. By 1915, the Russians had formally diagnosed Radio wave Sickness and set exposure standards for their country, leading the way in nnEMF exposure regulation. As industrialization and both World Wars came and went, humans living in cities with jobs in telecommunications and the military began being diagnosed with many environmentally caused diseases. Diabetes, cardiovascular diseases, and cancer rates all began to rise rapidly.

In the 1950s, Dr. Robert O. Becker and Dr. Andrew Marino began exposing the truth about power transmission nnEMF exposures and their related adverse health effects. At the same time, the first recorded cases of Alzheimer’s and Autism were documented in medical literature, sparking an explosion in brain diseases that would soon evolve into the categories of neurodegenerative, neurodevelopmental, and neuroimmunological diseases that are so common today.

In the 1970s, we were advised to fear the sun, leading to widespread use of sunglasses and sunscreen, accompanied by constant marketing campaigns about being 'sun smart' and avoiding the sun. This migration indoors led Americans to spend 50% of their day inside marking the beginning of vitamin D deficiency. In the 1980s and 1990s, Dr. Devra Davis, Dr. Martin Pall, Dr. Magda Havas, Alan Frey, Martin Blank, Nora Volkow and many more continued research as the power density of these fields increased, with exposures becoming globally widespread and impacting the health of plants, insects, animals, pets, livestock, and of course humans.

In 1992, the US government changed regulations for windows across the country, and shortly after, the rest of the world followed suit, to block infrared light (the predominant irradiation from the sun) from entering indoor environments. This left indoor environments energy efficient but humans within them energy deficient. Only a few years later, the technological revolution took hold, leading to widespread mobile phone use, Wi-Fi, Bluetooth, and 1G to 5G technologies. The average American home now contains 25 wireless pulsing devices, with regulations 20 years out of date and standards built for a fully grown male adult, despite children, adolescents, and women being the predominant exposure group. These standards are set to thermal effects, even though damage occurs far before a thermal effect is induced, and devices are rated to their maximum power individually but never tested together with compounding exposure from multiple devices, which is insanity given the sheer number of wireless devices used in the average home these days.

At the same time, the incandescent bulb was banned, removing the last source of infrared light from indoor environments and replacing it with narrow-band high-energy visible light (HEVL) rich in 450nm blue and 520nm green spikes of light, harming the brain, eyes, and nervous system through mechanisms such as the suppressive melatonin effect. This left indoor occupants severely deficient in red light with weak mitochondrial melatonin production and with the resulting epidemic of sleep dysfunction and insomnia. As a result, our bodies do not resolve daily inflammatory challenges as well and have weaker immune systems showing sensitivity to chemicals, radiation, food, toxins, mental challenges and lacking emotional resilience. Modern humans now live inside where there is no UV or IR light but instead are exposed to HEVL and 25 pulsing wireless devices, dehydrating our tissues and causing mitochondrial dysfunction, oxidative stress, chronic inflammation, and hypoxia. Infertility rates, neurological and ophthalmological diseases, cardiovascular diseases, immunological diseases, and organ-specific diseases like kidney disease are the highest they have ever been and continue to confound centralized medicine with governmental health care costs soaring above sustainably acceptable levels.

Despite sugar consumption being down in the past 40 years and calorie intake remaining the same, with more dietitians, diet books, nutritionists, gymnasiums, personal trainers, health wearables and health tracking apps, functional medicine testing and treatments, meditation guides, health coaches, breathwork experts and access to more healthcare services than ever before, chronic disease continues to escalate, and life expectancy is declining. It is not a lack of diet advice, a specific exercise program you’re not doing, a positive mindset you struggle to maintain or a missing supplement that is the problem, it’s the rapid shift in visible and non-visible light exposure on our eyes, skin, gut and lungs which has led to the explosion in neolithic disease across the board.  Our elderly are tethered to centralized medicine, extending life without quality. We are in a giant health experiment, having our health resilience tested daily for the sake of rapid technological and industrial progress. Implementation and execution of all technology over the past 140 years could have been done with health in mind, saving many lives and a lot of suffering. However, decision-makers either aren’t fully aware or are happy to make this trade-off on our behalf.

Therefore, it becomes a simple choice to take responsibility for our health, bringing it back into our own hands, creating a sleep sanctuary in our bedrooms where we can deeply rest, creating a safe environment for our children to play, learn and grow and cultivating a lifestyle which has optimal health built into it allowing you and your family to avoid being tethered to the centralized medical system setting the foundation to live a long, healthy life. Fortunately, we have the knowledge available, and despite realizing some inconvenient truths, we have the ability to empower ourselves, take back control of our mitochondrial health, and prevent chronic diseases before they necessitate an ‘all-in mission’ to reverse.

Our mitochondria, which produce all our energy and water within our bodies and create carbon dioxide allowing us to breathe in oxygen, have mitochondrial DNA (mtDNA) that is maternally inherited and contains 13 genes regulating this process. As soon as we stop producing energy, we die. Mitochondria form the centerpiece of health, and their state determines health or disease in the human living system. Even in the case of the <5% of genetic diseases such as Down syndrome, cystic fibrosis or Huntington's, improving mitochondrial health will still alleviate symptoms and prolong the inevitable much longer than otherwise. Dr. Douglas C Wallace has shared that we are only as strong as our weakest link, and our weakest link happens to have our weakest mitochondria, so strengthening these by removing barriers to healing and promoting health with additive strategies is perhaps the best approach to healing and thriving in a modern world.

The Mitochondrial origin of kidney disease

Mitochondrial dysfunction plays a significant role in the pathogenesis of both acute kidney injury (AKI) and chronic kidney disease (CKD). The kidneys' substantial energy demands for processes like solute reabsorption and secretion make them highly dependent on mitochondrial function. Damage to the mitochondria in the kidneys can arise from defects in mitochondrial structure, dynamics, and biogenesis, leading to increased oxidative stress, apoptosis, and ultimately, renal failure. Oxidative stress is linked to altered magnetic field exposure because the biophysics of magnetism involves the orientation of molecules with unpaired electrons, such as free radicals and reactive oxygen species (ROS). Additionally, mitochondrial dysfunction and the loss of electrical potential in cell membranes are critical factors in the pathogenesis of kidney disease, as the cell membrane voltage is influenced by the biophysics of electric fields. Mitochondria respond to the electromagnetic (light) force and even produce their own biophotons, further highlighting their role in cellular bioenergetics and injury.

Mechanisms of mitochondrial damage in kidney disease

1. Oxidative Stress: Mitochondria are a major source of reactive oxygen species (ROS). Excessive ROS production damage mitochondrial DNA, proteins, and lipids, leading to mitochondrial dysfunction and cell death. Generally this follows from a damaged superoxide pulse at complex 1 of the mitochondria in most metabolic conditions including diabetes.[study, study, study]

2. Impaired Mitochondrial Dynamics: Particularly dysregulation of fission and fusion, can lead to mitochondrial fragmentation, which is associated with the release of pro-apoptotic factors and cell death. However, smaller mitochondria themselves are not inherently inefficient—in fact, optimized fission can enhance energy efficiency and adaptability. It is swollen, dysfunctional mitochondria that signal inefficiency, while excessive fragmentation disrupts network connectivity and function, leading to metabolic dysfunction. [study]

3. Defective Mitophagy: Inefficient removal of damaged mitochondria through mitophagy can exacerbate mitochondrial dysfunction and contribute to the progression of kidney disease. [study]

4. Altered Bioenergetics: Mitochondrial dysfunction impairs ATP production, leading to an energy crisis in renal cells, which is particularly detrimental given the high energy demands of the kidneys.[study, study].
   
   

Loss of electrical potential in cell membranes can also contribute to kidney issues. The maintenance of electrochemical gradients across cell membranes is crucial for various cellular functions, including solute transport and cellular signaling. Disruption of these gradients can impair ATPase pumps and transporters, leading to cellular dysfunction and injury. For instance, the failure of ATP-binding cassette (ABC) pumps and other transporters due to loss of membrane potential can result in the accumulation of toxic substances within renal cells, further exacerbating mitochondrial damage and kidney injury.[study]

What happens next?

Once the foundations of kidney disease are setup, it doesn’t take long before blood pressure rises and poor circulation results all from reduced nitric oxide release from cytochrome c oxidase in the mitochondria and thus an inability to access stem cell depots so healing cannot take place effectively, insulin and leptin resistance occurs, calcium and deuterium leak into the cell cytoplasm adversely impacting intracellular water dynamics and raising mitochondrial heteroplasmy. If this continues the acute inflammation is unable to be resolved and turns into chronic higher than desirable inflammatory markers like highly sensitive c-reactive protein (hsCRP), Interleukin-6 (IL6), Monocyte chemoattractant protein-1 (MCP-1), and Transforming growth factor-beta (TGF-β), which can be measured as rising above their respective reference ranges indicating compromised kidney function drops.

Kidney disease occurs due to a variety of mechanisms that can lead to chronic kidney failure, ultimately necessitating dialysis. The primary mechanisms include:

Cites:

• "Pathogenesis of Chronic Kidney Disease: Mechanisms of Renal Fibrosis and Vascular Remodeling." Nature Reviews Nephrology.

• "Mechanisms of Disease: Chronic Kidney Disease and the Global Impact on Health." New England Journal of Medicine.

• "Pathophysiology of Chronic Kidney Disease and Acute Kidney Injury: The Interplay of Glomerular Hemodynamics and Tubulointerstitial Injury." Clinical Journal of the American Society of Nephrology.
  
  

As these mechanisms progress, they can lead to the gradual loss of nephron function. Nephrons are the functional units of the kidneys, and their loss reduces the kidneys' ability to filter blood and maintain fluid and electrolyte balance. Over time, this can result in chronic kidney disease (CKD) and, ultimately, end-stage renal disease (ESRD), where the kidneys can no longer function adequately to sustain life without dialysis or a kidney transplant.

Chronic Kidney Disease (CKD) Stages

• Stage 1 CKD: Kidney damage with normal or high GFR (≥90 mL/min/1.73 m²) but with markers of kidney damage such as proteinuria.

• Stage 2 CKD: Mild reduction in GFR (60-89 mL/min/1.73 m²) with markers of kidney damage.

• Stage 3 CKD: Moderate reduction in GFR (30-59 mL/min/1.73 m²), often with noticeable symptoms like fatigue, swelling, and changes in urination.

• Stage 4 CKD: Severe reduction in GFR (15-29 mL/min/1.73 m²), with more pronounced symptoms and complications such as anemia, bone disease, and cardiovascular issues.

• Stage 5 CKD: End-stage renal disease (ESRD) with GFR <15 mL/min/1.73 m², centralized medicine says this requires dialysis or kidney transplant for survival.

• Dialysis is said to be required by centralized medicine when kidney function drops below a critical threshold (usually when glomerular filtration rate, GFR, falls below 15 mL/min/1.73 m²). Dialysis performs the essential functions of the kidneys, such as removing waste products, excess fluids, and maintaining electrolyte balance, which are vital for sustaining life. Three are two main types of dialysis: 1. Hemodialysis: Blood is filtered through a machine outside the body and returned to the body after being cleaned. 2. Peritoneal Dialysis: The lining of the abdomen (peritoneum) acts as a natural filter, with a special fluid introduced into the abdomen to absorb waste products and then drained away.

• However, just like most centralized treatments for chronic disease, the treatment provides a crutch for the body, and it usually never gets better unless complementary approaches are used. This is where repairing the mitochondrial function and metabolism within the kidneys, improving the voltage within the blood cells and depleting the deuterium from the blood becomes a useful complementary approach.

Blood and Immune System Consequences of Poor Kidney Function

Erythropoiesis and Red Blood Cell Creation: The process of erythropoiesis, or the creation of new red blood cells (RBCs), is critically dependent on the presence of healthy mitochondria, sufficient amounts of vitamin D, DHEA, and Testosterone, in that order. These elements stimulate RBC production from the bone marrow and require a DC electric current with an amperage of 1 trillionth of an amp. This tiny electrical current is the foundation of all regeneration and healing in human biology. However when there is excessive non-native EMFs like the 25 wireless devices, dirty electricity or AC magnetic fields in the home this regenerative current is destabilized and regeneration and RBC creation cannot occur as it should within the living system, not to mention the suppressive effects of nitric oxide which closes the door to accessing stem cell depots in the body, collapsing the coherent domain clusters within biological water and impeding mitochondria’s ability to produce water to hydrate essential biopolymers like collagen and melanin needed for effective photoelectric communication around the body to create new cells and regenerate. The protein erythropoietin, produced within the kidneys in response to low oxygen levels in the blood, plays a key role in this process. Optimal RBC creation is facilitated by adequate full spectrum light exposure especially UV and IR together, mitigating all non-native EMFs from radiofrequency radiation to artificial narrowband blue light, proper nutrition and hydration, and avoiding over-breathing or mouth breathing, especially during sleep. However, poor kidney function impairs the production of erythropoietin, resulting in compromised photoelectric ability of blood plasma.

Kidney Failure and Membrane Charge Ability

Kidney failure represents an extreme loss of membrane charge ability. This condition also hampers the body's ability to synthesize Vitamin D. The kidneys require UV light to regenerate via activation of the POMC genes, as they contain the POMC polypeptide and its products, including ACTH, which have been found in the kidneys.

Key Points of Kidney Failure

• Proximal Convoluted Tubule (PCT) Absorption: The proximal convoluted tubule absorbs 70% of kidney processing. The Glomerular Filtration Rate (GFR) measures the rate of filtration into Bowman’s capsule.

• Indicators of Kidney Function: In low GFR (Low Flow State), Blood Urea Nitrogen (BUN) levels double (filtered and reabsorbed), and creatinine levels increase (filtered and secreted but not reabsorbed). Creatinine, a byproduct of muscle breakdown, is higher in individuals with more muscle mass. A decrease in GFR by 50% is required before serum creatinine levels change. Conversely, in a good state, GFR increases, BUN decreases, and creatinine levels drop.

• BUN/Creatinine Ratio: During impaired kidney function, BUN/Creatinine Ratio values do not accurately reflect hydration levels. So, this blood marker goes from being a good indicator to track when kidneys are functioning well, to a poor biomarker when kidney function is poor.
  
  

Vitamin D and Kidney Function

Poor kidney function is often associated with low Vitamin D levels. Synthesized from sunlight exposure, Vitamin D lowers blood pressure, reduces inflammation in the kidneys, and acts as a natural antibiotic. Therefore, maintaining healthy kidney function is essential for adequate Vitamin D synthesis and overall health. When the kidneys are damaged, the synthesis of vitamin D is reduced because the kidneys play a key role in converting vitamin D into its active form. However, the liver still contributes to some degree of vitamin D metabolism, so it remains possible for the body to synthesize vitamin D endogenously, albeit at a reduced rate. In cases of severe kidney dysfunction, supplementing vitamin D may be beneficial, but it is still important to get UV light exposure on the skin. Sunlight helps keep mitochondria healthy and supports overall cellular function. At the same time, exposure to sunlight can enable the liver and any remaining kidney function to continue synthesizing vitamin D, assisting in the healing process.

• References:

• Vitamin D Status and All-Cause Mortality in Patients With Chronic Kidney Disease: A Systematic Review and Dose-Response Meta-Analysis. Jayedi A, Soltani S, Shab-Bidar S. The Journal of Clinical Endocrinology and Metabolism. 2017;102(7):2136-2145. doi:10.1210/jc.2017-00105. https://pubmed.ncbi.nlm.nih.gov/28453636

• Association Between Vitamin D Deficiency and Health-Related Quality of Life in Patients With Chronic Kidney Disease From the KNOW-CKD Study. Oh TR, Kim CS, Bae EH, et al. PloS One. 2017;12(4):e0174282. doi:10.1371/journal.pone.0174282. https://pubmed.ncbi.nlm.nih.gov/28448520 

Vit D Supplementation guidance (Always check with your MD)

• In the study titled "Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients," the authors discuss the use of vitamin D supplementation in Chronic Kidney Disease (CKD) patients, particularly those in advanced stages, including dialysis and kidney transplant recipients.

• The study highlights that nutritional vitamin D formulations (like cholecalciferol and ergocalciferol) are less effective at suppressing parathyroid hormone (PTH) and managing secondary hyperparathyroidism (SHPT) compared to active vitamin D analogs such as calcitriol. However, even with supplementation, significant improvements in vitamin D status and PTH levels can still be achieved, especially when 25-hydroxyvitamin D levels are increased above 50.8 ng/mL.

• One important point raised in the study is that vitamin D supplementation is particularly effective in preventing the worsening of PTH levels and mineral imbalances rather than reversing already high PTH in advanced CKD patients. It also notes that higher doses of vitamin D may be required to achieve better results in improving bone health and controlling SHPT, especially in patients with severe CKD.

• In conclusion, the study suggests that native vitamin D supplementation plays a crucial role in managing vitamin D deficiency in CKD patients, helping control SHPT and improve bone health, but higher doses or active vitamin D analogs may be required for patients in the later stages of CKD or those on dialysis.

Study: https://www.mdpi.com/2072-6643/13/5/1453 

Conclusion

The biophysics perspective of health explains how modern alterations to our physics environment especially as it pertains to light and magnetic flux have led to most, if not all chronic diseases. This approach is governed by the principles of Light, Water, and Magnetism, collectively referred to as Circadian Biology or Epigenetics, which emphasizes that environmental stimuli control genetic expression. The principle is that health issues often stem from environmental factors rather than internal ones, and recovery necessitates changing the environment in which the sickness developed.

The body's environmental sensors, the cell membranes and mitochondria, are crucial in understanding and reversing mitochondrial diseases, including kidney disease. Light exposure is the primary regulator of our epigenome. Food is essentially stored light, and the water we consume and produce within our cells helps harness this light for biological processes. Magnetic fields synchronize and optimize the behavior of electric charges and light within our system. Health issues arise from disturbances in light exposure, water quality, and magnetic fields, such as artificial light, fluoridated or chlorinated water, and electromagnetic radiation from devices and power lines. Mitigating these factors enhances resilience and health.

Historically, humans evolved with natural sunlight, earth contact, firelight, and natural water sources, which provide essential biological signals for health and longevity. Kidney function is linked to the energy or electric charge of kidney cells. Optimizing mitochondrial function and sleep is crucial for increasing energy production and healing. A fundamental strategy is to watch the sunrise daily, as natural light exposure tunes the circadian rhythm, initiating an optimal hormonal cascade via the pituitary/endocrine system, and obtaining 15-30 minutes of midday ultarvioelt light form the sun. And of course, block artificial light after sunset whilst sleeping in a radiation free bedroom.